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Literature summary for 2.7.7.6 extracted from

  • Agapov, A.; Esyunina, D.; Kulbachinskiy, A.
    Gre-family factors modulate DNA damage sensing by Deinococcus radiodurans RNA polymerase (2019), RNA Biol., 16, 1711-1720 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.6

Inhibitors

Inhibitors Comment Organism Structure
DNA various DNA lesions significantly affect the efficiency and fidelity of RNA synthesis. DNA modifications that disrupt correct base-pairing can strongly inhibit transcription and increase nucleotide misincorporation by RNAP. The universal transcription factor GreA and Deinococcus-specific factor Gfh1 stimulate RNAP stalling at various DNA lesions, depending on the type of the lesion and the presence of Mn2+ ions Deinococcus radiodurans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Deinococcus radiodurans
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Deinococcus radiodurans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Deinococcus radiodurans diphosphate + RNAn+1
-
 ?
nucleoside triphosphate + RNAn various DNA lesions significantly affect the efficiency and fidelity of RNA synthesis. DNA modifications that disrupt correct base-pairing can strongly inhibit transcription and increase nucleotide misincorporation by RNAP. The universal transcription factor GreA and Deinococcus-specific factor Gfh1 stimulate RNAP stalling at various DNA lesions, depending on the type of the lesion and the presence of Mn2+ ions Deinococcus radiodurans diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
RNAP
-
 Deinococcus radiodurans